Payers ranked by Part D membership | 2025

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Centene’s Medicare Part D enrollment is nearing 8 million members.

According to CMS enrollment data from March 2025, Centene leads the nation in Medicare Part D membership with 7.92 million enrollees. The company has gained nearly 1 million members since the end of 2024, when its Part D enrollment was 6.93 million.

Here’s how the largest insurers stack up on Medicare Part D membership:

  • Centene: 7.92 million
  • CVS Health: 4.16 million
  • UnitedHealth Group: 3.58 million
  • The Cigna Group: 3 million
  • Humana: 2.3 million
  • Elevance Health: 426,871
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