Five of the 10 drugs with the highest Medicare Part D spending are diabetes treatments, including Ozempic, according to an analysis from KFF.
The report, published July 12, found the 10 drugs with the highest Medicare costs accounted for 22 percent of Part D spending in 2022.
Later this year, CMS will publish 10 drugs selected to negotiate with the agency for Medicare pricing for 2026. KFF's report noted two of the most expensive drugs will not be eligible for negotiation because they are too new, and three will not be eligible because they have biosimilar competitors.
Editor's note: Spending amounts reflect gross spending and do not account for rebates that may result in lower net spending.
Here are the 10 drugs Medicare spent the most on in 2022:
1. Eliquis (Bristol-Myers Squibb)
2021 spending: $12.6 billion
Number of users in 2021: 3.1 million
Uses: Blood thinner to prevent strokes and blood clots
2. Revlimid (Bristol-Myers Squibb)
2021 spending: $5.9 billion
Number of users in 2021: 45,600
Uses: Treats myelodysplastic syndrome and multiple myeloma
3. Xarelto (Johnson & Johnson and Bayer)
2021 spending: $5.2 billion
Number of users in 2021: 1.3 million
Uses: Blood thinner to treat and prevent blood clots
4. Trulicity (Eli Lilly)
2021 spending: $4.7 billion
Number of users in 2021: 663,900
Uses: Treats Type 2 diabetes
5. Januvia (Merck)
2021 spending: $4.1 billion
Number of users in 2021: 934,500
Uses: Treats Type 2 diabetes
6. Jardiance (Boehringer Ingelheim)
2021 spending: $3.7 billion
Number of users in 2021: 884,500
Uses: Treats Type 2 diabetes
7. Imbruvica (AbbVie and Johnson & Johnson)
2021 spending: $3.2 billion
Number of users in 2021: 26,000
Uses: Treats some types of leukemia and lymphoma
8. Humira (AbbVie)
2021 spending: $2.9 billion
Number of users in 2021: 51,200
Uses: Treats rheumatoid arthritis, Crohn's disease and other conditions
9. Lantus Solostar (Sanofi)
2021 spending: $2.8 billion
Number of users in 2021: 1.1 million
Uses: Insulin to treat Type 1 and Type 2 diabetes
10. Ozempic (Novo Nordisk)
2021 spending: $2.6 billion
Number of users in 2021: 458,600
Uses: Treats Type 2 diabetes